Thirty-six-year-old Michael Nalewaja had built a stable, quiet life as an electrician in Alaska, nearly 20 years removed from a teenage battle with drug addiction that led him to rehabilitation. That peaceful existence ended abruptly just days before Thanksgiving 2025, when Nalewaja and a mutual friend unknowingly consumed a deadly combination of fentanyl and carfentanil, which they had mistaken for cocaine.
Kelley Nalewaja, Michael’s mother, recalled the devastating phone call she received from her son’s wife: “I heard the word ‘autopsy’ and I literally just collapsed to the floor. Even if somebody had been there prepared with Narcan — even if somebody had called 911 in time — he was not going to survive.”
Michael’s death is far from an isolated tragedy. Authorities are now sounding the alarm over a dramatic resurgence of carfentanil, a weapons-grade synthetic opioid 10,000 times more potent than morphine and 100 times stronger than standard fentanyl, that has killed hundreds of unsuspecting drug users across the United States. This growing public health threat has emerged against a backdrop of an unprecedented multi-year decline in both overall drug overdose deaths and fentanyl seizures, a shift that experts and law enforcement trace to new regulatory controls.
Following a recent Chinese government crackdown on the sale of chemical precursors used to manufacture illicit fentanyl, Mexican drug trafficking organizations have turned to carfentanil to boost the potency of diluted fentanyl supplies, according to Drug Enforcement Administration (DEA) intelligence bulletins reviewed by The Associated Press. This is not the first time carfentanil has penetrated the North American drug market: a decade ago, the substance caused a wave of mass overdoses before Chinese regulatory controls and U.S. enforcement cracked down on its supply, driving incident numbers sharply down.
That trend has reversed dramatically in just a few short years. DEA laboratory data obtained by the AP shows that agents identified carfentanil in 1,400 separate drug seizures across the U.S. in 2025. That number marks a drastic jump from just 145 positive identifications in 2023 and only 54 in 2022. Law enforcement officials say Mexican cartels are now either experimenting with domestic carfentanil production or sourcing the substance from Chinese vendors who evade Beijing’s regulations by advertising on unregulated online forums hosted in third countries.
Manufacturing carfentanil carries extreme risk even for experienced traffickers, notes Frank Tarentino, the DEA’s chief of operations for the Northeast region covering Maine to Virginia. “You can’t just dabble in this. This is not some mad scientist on Reddit you’re going to get to go out to a rudimentary laboratory in Mexico to make carfentanil,” he explained. For people struggling with opioid dependence who purchase unregulated drugs on the street, the risk is unparalleled: a dose smaller than a grain of salt is enough to cause lethal overdose, and even high multiple doses of naloxone — the life-saving overdose-reversing medication — are often ineffective against carfentanil exposure. “This presents an extremely frightening proposition for substance abuse dependent people who seek opioids on the street today,” Tarentino added.
The resurgence of carfentanil comes at a moment of rare progress in the U.S. overdose crisis. Overall drug overdose deaths have fallen for more than two years, the longest sustained decline in decades. Experts attribute this drop to multiple factors, including wider distribution of naloxone, expanded access to evidence-based addiction treatment, and international regulatory changes targeting fentanyl precursor production. Fentanyl seizures at the U.S. border have also plummeted: U.S. Customs and Border Protection reports that seizures fell to roughly 12,000 pounds in 2025, less than half the total seized in 2023.
Even with this progress, the DEA has maintained fentanyl and emerging synthetic opioids as its top enforcement priority, recently requesting a $362 million budget increase focused exclusively on combating cartel-driven trafficking. Sara Carter, the White House drug czar under the current administration, framed the crisis as an deliberate act of harm. “Anyone who takes a pill that is not prescribed to them by their doctor is playing a game of Russian roulette with their life,” Carter said. “But if those terrorists think they can continue this chemical warfare without consequences, they are wrong.”
Public health experts and drug policy specialists warn that carfentanil’s unique deadliness makes its resurgence an especially alarming threat. Originally developed and researched for use as a chemical weapon, carfentanil was infamously deployed by Russian forces against Chechen separatists during a 2002 hostage crisis. Today, the only legal use for the substance in the U.S. is as a tranquilizer for large zoo animals such as elephants, with the DEA capping annual legal manufacturing at just 20 grams — an amount small enough to fit in the palm of a hand.
“If the world thinks we had a problem with fentanyl, that’s minute compared to what we’re going to be dealing with with carfentanil,” said Michael King Jr., founder of the Opioid Awareness Foundation, comparing the substance to a biological weapon. The most recent Centers for Disease Control and Prevention data underscores this risk: in 2024, overdose deaths linked to carfentanil nearly tripled from the previous year, totaling 413 deaths across 42 states and Washington, D.C. While carfentanil’s overall prevalence still trails that of standard fentanyl, experts warn it could spread rapidly across the country without targeted law enforcement intervention to cut off supply chains.
In recent months, the DEA has already intercepted large shipments of carfentanil-laced counterfeit pills. In October 2025, the agency’s Los Angeles field division seized 628,000 pills laced with carfentanil; just one month prior, officials in Washington state seized more than 50,000 counterfeit M30 opioid pills at a gas station, which tested positive for a lethal mixture of carfentanil and acetaminophen.
Traffickers are drawn to carfentanil for the same economic reason that drove the rise of fentanyl years ago: extremely small amounts can produce a massive supply of cut street drugs, generating enormous profits. Rob Tanguay, senior medical lead for addiction services at Canadian health agency Recovery Alberta, added that some frequent opioid users who have developed tolerance to standard fentanyl actively seek out carfentanil for its more intense high, despite the well-documented lethality. “The toughest part about all of this is that this is all about money,” Tanguay said.
For Kelley Nalewaja, the loss of her son — a charismatic electrician who recently earned a national award from his industry union — has turned private grief into public advocacy. Instead of holding a large funeral, she organized a community town hall in her hometown of El Dorado Hills, California, bringing together local leaders and other bereaved families who have lost loved ones to illicit synthetic opioids. She is now pushing for sweeping legislative and policy changes to curb carfentanil trafficking, arguing the substance was never intended for human consumption. “It’s not an OD; it’s not an overdose,” she said. “It’s a murder weapon.”