分类: health

  • Congo’s Ebola outbreak records one of its highest weekly death tolls yet

    Congo’s Ebola outbreak records one of its highest weekly death tolls yet

    BUNIA, Democratic Republic of Congo – Fresh government data released Monday has revealed a catastrophic milestone in the ongoing Ebola crisis gripping eastern Congo, with more than 300 fatalities recorded in the past seven days alone — one of the sharpest weekly death tolls since the outbreak began. As frontline health teams fight against overwhelming odds to contain the virus, the epidemic is spreading at a rate never before seen in global Ebola history.

    According to figures from Congo’s Ministry of Health, as of Saturday, the outbreak has been linked to 5,514 confirmed and probable cases, with a total of 2,642 deaths nationwide. The 317 new fatalities reported over the previous week mark a dangerous acceleration in the virus’s spread. Congolese public health experts warn the true scale of the crisis is far worse than official numbers indicate, noting the virus was circulating undetected for weeks before the outbreak was formally confirmed, and the actual case count could be three times higher than currently documented.

    This outbreak, caused by the rare Bundibugyo Ebola variant, is now the fastest-growing on record. A large share of deaths are occurring outside of formal treatment centers, and at this stage of the outbreak, the death toll is already seven times higher than that of the 2014–2016 West Africa Ebola outbreak at the same point, despite that outbreak eventually becoming the deadliest in history with more than 11,000 total fatalities.

    Ituri province remains the epicenter of the crisis, and data shows that most new infections are still occurring among people who were not part of monitored contact tracing networks, making early intervention and isolation nearly impossible. The overall national case fatality rate currently stands at 47.9%, but hard-to-access regions like neighboring North Kivu province face far deadlier outcomes, with a fatality rate reaching 68.6% according to government data.

    One of the biggest barriers to containing the spread has been the absence of formally approved vaccines or targeted treatments for the rare Bundibugyo variant driving this outbreak. In a small glimmer of progress, Congo received more than 16,000 doses of the Ervebo vaccine on Friday — a jab that has proven highly effective against the more common Zaire Ebola variant in past outbreaks. The World Health Organization has announced that the doses will first be offered to frontline medical workers, and will also be used to support clinical trials for a Bundibugyo-specific vaccine.

    While early laboratory and animal studies suggest Ervebo may offer some cross-protection against the Bundibugyo variant, public health officials have not yet confirmed its effectiveness against this specific strain. Authorities have not yet announced a timeline for rolling out the vaccine doses to at-risk frontline workers, but local residents in Ituri expressed cautious optimism that the arrival of vaccines will help turn the tide of the outbreak.

    “I am very pleased that these vaccines have finally arrived,” said Héritier Ramazani, a local Ituri resident. “We are fed up with recording new cases of Ebola every day.”

    The response effort is already hindered by a collection of overlapping challenges that make containing the virus extraordinarily difficult. The outbreak is centered in a region plagued by ongoing rebel violence that puts response teams at constant risk, alongside massive, unregulated population movements that help the virus spread across provincial and national borders. Medical teams also face unpaid salaries that have led to repeated work stoppages, deep-seated community mistrust built from decades of conflict, poor road infrastructure that slows access to remote communities, and widespread misinformation that claims Ebola does not exist at all.

    Epidemiologists tracing the outbreak’s origins believe the virus began spreading in the mining town of Mongbwalu as early as February, roughly three months before Congolese authorities officially declared the outbreak on May 15. The months of undetected transmission allowed the virus to take hold across multiple communities before response efforts could even begin.

  • China probes use of formaldehyde to keep cabbages fresh

    China probes use of formaldehyde to keep cabbages fresh

    As the world’s leading cabbage producer, accounting for nearly half of the global annual output that exceeds 30 million metric tons, China is now facing a fresh food safety scare that has sparked nationwide attention. Hebei Province, a key growing and distribution hub in the country’s northeast, has confirmed that authorities have launched a full investigation following the emergence of footage showing cabbage handlers dipping heads of the vegetable in a preserving solution before loading them onto transport trucks.

    The controversial footage was first brought to public attention by an independent environmental blogger last week. In China, the use of formaldehyde — a colorless, carcinogenic chemical — for any food preservation purpose is banned under strict national food safety regulations. Most of China’s cabbage output is distributed domestically, with a large share also exported to neighboring Asian markets and Russia, with South Korea and Vietnam counting among the top international buyers.

    State media reports confirm that local police have already initiated legal proceedings against the individuals identified as being involved in the practice. In response to growing public concern, national and local regulators have moved quickly to head off widespread consumer panic and rebuild public trust in the country’s fresh vegetable supply. Authorities are rolling out widespread random spot checks of cabbage stocks at wholesale and retail markets across every region of the country.

    Investigators are also working to determine how widespread the illegal practice of formaldehyde dipping is across the cabbage industry, and have implemented tracing protocols to isolate and remove any affected produce from the supply chain. In an official public statement released Saturday, administrators from Kangbao County, the region at the center of the initial reports, reaffirmed their commitment to upholding food safety standards: “Any illegal or non-compliant practices discovered will be dealt with strictly in accordance with the law to ensure the safety of the vegetable supply.”

    Beijing’s Xinfadi Market, the largest wholesale fresh produce hub serving the Chinese capital, released its own statement confirming that it had completed a full audit of its cabbage supply chains, and that no contaminated produce had entered the market’s distribution network.

    The incident has dominated domestic Chinese media coverage and sparked intense public discussion. In an official editorial, People’s Daily, the official newspaper of the Chinese Communist Party, issued a sharp rebuke of the actors involved: “The wholesalers focused solely on their immediate economic interests while completely disregarding the lives and health of consumers. [They] crossed a legal red line and breached the moral bottom line.”

    According to the American Cancer Society, while prolonged exposure to high concentrations of formaldehyde in occupational settings has been definitively linked to multiple forms of human cancer, the long-term health impacts of low-level exposure through food consumption remain understudied and not clearly understood.

  • Congo receives more than 16,000 doses of Ebola vaccine as it grapples with unprecedented outbreak

    Congo receives more than 16,000 doses of Ebola vaccine as it grapples with unprecedented outbreak

    BUNIA, Democratic Republic of the Congo – As the Central African nation fights what has become the fastest-spreading Ebola outbreak in recorded history, its first shipment of 16,250 doses of the Ervebo vaccine has arrived on the ground, the country’s health minister confirmed.

    The vaccine shipment touched down at Kinshasa’s N’djili International Airport on Friday evening. This delivery marks the first installment of the 70,000 total doses promised to Congo by the World Health Organization and its global health partners, an aid package first announced publicly this past Thursday. Additional shipments of more vaccine doses are scheduled to arrive in the country early next week, according to official updates.

    The unfolding public health crisis is being driven by the Bundibugyo Ebola virus strain, a rare variant that currently has no specifically approved treatment or licensed vaccine designed exclusively to target it. The virus presents a unique challenge to containment: its early symptoms overlap heavily with common regional illnesses like malaria, allowing infections to go undetected while the virus spreads easily through communities.

    While Ervebo is formally approved only for another common Ebola strain, it has a proven track record of successfully stopping transmission in past outbreaks. WHO public health experts have indicated the vaccine may still offer meaningful cross-protection against the Bundibugyo variant, making it a critical stopgap tool while more targeted medical countermeasures are developed.

    As of Friday’s official count, the outbreak has already claimed 2,516 lives among 5,290 confirmed confirmed cases. The rate of spread is unprecedented, and public health officials warn the outbreak is on course to overtake the 2014-2016 West African Ebola epidemic, the deadliest on record which killed more than 11,000 people across five countries. Data analysis from the Africa Centers for Disease Control and Prevention shows transmission has not yet reached its peak, with projections indicating the known infection rate could triple in coming weeks if containment efforts cannot slow spread.

    Complicating all response efforts are a series of overlapping humanitarian and security crises that have blocked access to affected communities. Much of the outbreak’s epicenter is controlled by rebel groups engaged in active armed conflict with the Congolese government, making it dangerous for response teams to operate. Medical workers and facilities have repeatedly been targeted in attacks, while large populations of displaced people and mobile migrant laborers have helped the virus cross regional borders. The lack of basic healthcare infrastructure in affected regions has further undermined efforts to test, trace, and isolate cases.

  • Ebola vaccine trial to start in DR Congo as warning issued over speed of infections

    Ebola vaccine trial to start in DR Congo as warning issued over speed of infections

    The Democratic Republic of the Congo (DRC) has launched a new phase of its battle against a historic Ebola outbreak, rolling out an existing vaccine for clinical trials to test its effectiveness against the rare Bundibugyo strain that is currently driving the spread of the virus. As the World Health Organization (WHO) warns that infections are growing at an exponential rate across large swathes of northern and eastern DRC — an area larger than the entire country of France — the death toll from the three-month outbreak has already climbed to nearly 2,500, with half of these fatalities recorded in just the last 20 days.

    This outbreak is already the deadliest ever recorded in DRC and the second-worst Ebola outbreak in global history, outstripped only by the devastating 2014–2016 West Africa epidemic that killed more than 11,000 people. Experts now believe the Bundibugyo strain has been circulating in the country since as early as February, but initial cases were misdiagnosed as more common regional illnesses including typhoid and malaria, creating a critical delay in response efforts.

    Multiple barriers have continued to slow containment work. Years of armed conflict in eastern DRC has left large areas of territory inaccessible to official public health teams, while deep-rooted local suspicion of government health authorities and traditional burial practices that involve close contact with deceased bodies have further accelerated transmission. A new analysis from international children’s charity Save the Children estimates that at least 180 Congolese children have been orphaned, losing both parents or primary caregivers to the virus since the outbreak began.

    In a new effort to turn the tide of the crisis, the existing Ervebo vaccine — which is already proven to protect against the more common Zaire strain of Ebola — will be deployed in a large-scale clinical trial. Under the plan agreed with global health bodies, 20,000 doses of Ervebo will be used to test how well it works against the Bundibugyo strain, for which no effective vaccines or treatments have yet been validated. An additional 50,000 doses will be prioritized for frontline health workers, who have faced extraordinarily high risk of infection during the response. Both the WHO and the Africa Centres for Disease Control and Prevention have welcomed the vaccine allocation, framing it as a critical reinforcement for the under-resourced response to the rapidly spreading outbreak. Strict new safety protocols have also been put in place for burials to cut the risk of transmission from infected remains.

    The ongoing conflict has added unprecedented complexity to the crisis. The M23 rebel alliance, which seized control of major eastern cities including Goma and Bukavu in early 2025 and holds large portions of North Kivu province, has launched its own parallel Ebola response in the territories it controls. After confirming two positive Ebola cases in a village under its control, M23 authorities recently announced a 30-day suspension of shared taxis and passenger boat travel between rebel-held and government-held areas of North Kivu, effective this Saturday. All other cross-area transport will remain operational but subject to strict public health screening. The rebel group had declared its territories Ebola-free in late June, and the new restrictions highlight how armed divisions have fragmented the response to a unified public health threat.

    Ebola is an extremely virulent viral disease, and the Bundibugyo strain is one of the rarest variants, with only two documented prior outbreaks recorded globally. Initial symptoms of infection mirror those of common regional illnesses, including sudden fever, headache, and fatigue, and can develop anywhere from two to 21 days after exposure. As the infection progresses, patients often develop severe vomiting and diarrhea that can lead to fatal organ failure. The virus spreads through direct contact with infected bodily fluids such as blood or vomit, making infection control particularly challenging in low-resource, conflict-affected settings.

  • 2,500 dead and rising — UN says DR Congo Ebola outbreak ‘growing exponentially’

    2,500 dead and rising — UN says DR Congo Ebola outbreak ‘growing exponentially’

    An Ebola outbreak raging across the Democratic Republic of Congo (DRC) is spreading at an exponential rate, with the official death toll surging past 2,500 and half of those fatalities recorded in just the last 20 days, the United Nations’ senior Ebola response coordinator confirmed Friday.

    This outbreak, the 17th recorded Ebola event in DRC history, is already the deadliest the country has ever faced, and is expanding faster than any previous Ebola outbreak on record. Speaking to reporters via remote connection from Bunia – the outbreak’s epicenter – Julien Harneis, the UN’s top coordinator for the crisis, painted a stark picture of the rapidly worsening situation.

    “The epidemic is spreading widely. It’s now covering an area that is bigger than France…. It is growing faster and wider than the Ebola response,” Harneis said. Experts believe the outbreak began spreading quietly for several weeks before it was officially declared by DRC authorities on May 15, giving the virus a critical head start on containment efforts.

    The virus has taken hold primarily in northern and eastern regions of DRC, where long-standing systemic vulnerabilities have created a perfect environment for unchecked spread: weak central government presence, crumbling and under-resourced health infrastructure, and decades of activity by dozens of armed armed groups that have destabilized communities.

    The international medical charity Doctors Without Borders (MSF) echoed the UN’s alarm Friday, warning the outbreak is accelerating “at an alarming rate.” “This epidemic continues to spread, moving faster than the response can keep up,” MSF president Javid Abdelmoneim said in an official statement.

    The ongoing response effort has faced widespread criticism for its slow rollout and poor coordination, and is further complicated by deep-rooted mistrust of medical authorities among local populations. To date, confirmed cases have been reported across six DRC provinces, with some cases detected near the South Sudan border and a previous cluster in neighboring Uganda. Uganda, which recorded 20 cases and two deaths before containing its outbreak, declared itself Ebola-free last month.

    Complicating response efforts further, the current outbreak is driven by the Bundibugyo Ebola strain, for which no specifically approved vaccine or targeted treatment exists, though multiple clinical trials are currently underway. The World Health Organization (WHO) announced Thursday that DRC will receive 70,000 doses of Ervebo, an approved vaccine that has proven highly effective against the more common Zaire Ebola strain.

    Earlier this month, WHO vaccine experts endorsed a full-scale human trial of Ervebo to test whether it provides cross-protection against the Bundibugyo strain. While early data from animal trials suggests the vaccine may offer partial protection, WHO spokesman Christian Lindmeier emphasized Friday that “it is not yet known whether Ervebo is protective against the Bundibugyo virus in humans.”

    Bringing the outbreak under control, which spreads through direct contact with infected bodily fluids and causes life-threatening hemorrhagic fever, faces a host of additional barriers. Harneis pointed to widespread insecurity across eastern DRC and a chronically weak public health system as major obstacles.

    “The law and order is undermined, and the basic services, particularly health, have been fragmented,” he said, describing working conditions for frontline responders as “brutal.” Since the outbreak began, 160 healthcare workers have contracted Ebola, and 43 of those workers have died. Frontline teams have also faced repeated targeted attacks on ambulances and response facilities.

    Harneis added that a barely functional banking system has made it difficult to deliver timely wages to response workers, while recent cuts to international funding have reduced the response capacity of humanitarian organizations operating in the region by one third.

    In closing, Harneis issued an urgent call for expanded international support and resources. “If we provide more staffing, if we get more resources into remote areas across … the east of the Democratic Republic of Congo, within months we can slow the transmission and move to stopping it,” he said. “If we do not, … then this epidemic will become more deadly. It will spread wider and it risks to spread into neighbouring countries.”

  • Rare disease drug Tavneos recalled in Republic of Ireland

    Rare disease drug Tavneos recalled in Republic of Ireland

    A critical recall of the rare autoimmune disease treatment Tavneos (generic name Avacopan) is now underway across the Republic of Ireland, following a sweeping decision by European regulators to pull the drug from the regional market.

    Manufactured by U.S.-based biotechnology giant Amgen and distributed globally through a network of regional partner pharmaceutical firms, Tavneos is specifically designed to treat adults living with severe, rare autoimmune conditions that trigger dangerous inflammation of blood vessels. Until recently, it had been authorized for use across the European Union, including Ireland.

    The chain of regulatory action began earlier this year, when Japanese pharmaceutical firm Kissei – which holds marketing rights to Tavneos in Japan – published safety data in May covering more than 8,500 Japanese patients treated with the drug since its 2022 launch in the country. The data showed 20 patient deaths among this treated group. To date, regulators have not confirmed whether Tavneos was the direct cause of these fatalities, and Amgen has previously pushed back on causal links, noting that “these figures include cases for which a causal relationship with the product could not be determined.”

    Despite the unresolved connection, European drug regulators moved forward with restrictive action. In July, the European Medicines Agency (EMA), the EU’s top drug safety body, issued a formal recommendation to revoke Tavneos’ existing marketing authorization across the bloc. The European Commission, the EU’s executive arm, finalized and approved that recommendation earlier this August.

    In line with the EU decision, Irish health regulators have moved quickly to implement the recall. Distribution of Tavneos from Irish pharmaceutical wholesalers halted on 11 August, and on Thursday, the Health Products Regulatory Authority (HPRA), Ireland’s national drug safety watchdog, issued an official order to recall all remaining wholesale stock of the drug.

    According to reports from Irish public broadcaster RTÉ, around 60 patients in Ireland received Tavneos treatment before the EMA’s recommendation was issued. The HPRA clarified that the drug was only ever prescribed by specialist consultants with specific expertise in managing these rare vascular autoimmune conditions, and many of these clinicians had already begun transitioning patients to alternative treatments ahead of the formal recall.

    For patients currently undergoing treatment with Tavneos, the HPRA issued a clear public advisory: do not discontinue use of the drug without first consulting your treating specialist physician, to avoid dangerous health complications from unmanaged disease.

    The recall is not limited to Ireland. France’s national drug safety agency, ANSM, has announced that a full recall of all existing Tavneos batches across the country will launch on 19 August. Across the English Channel, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) confirmed back in June that it was conducting its own independent review of Tavneos’ benefits and risks, and has not yet issued a final decision. Outlets have contacted the MHRA for additional comment on the agency’s current stance following the EU’s withdrawal of authorization.

  • Tasmanian childcare centre on alert after child treated for tuberculosis, parents contacted

    Tasmanian childcare centre on alert after child treated for tuberculosis, parents contacted

    A northern Tasmanian childcare centre has activated public health protocols after health authorities confirmed a child who attended the facility was treated for tuberculosis, a rare but potentially fatal bacterial infection if left unaddressed.

    Goodstart Early Learning, which operates the Kings Meadow-based centre, was notified of the confirmed case by Tasmanian public health officials last week. According to a company spokesperson, the infected child has not set foot at the centre since mid-July, and also attended a second local childcare facility before the diagnosis.

    While tuberculosis causes roughly 1.3 million deaths globally each year, the disease is extremely uncommon in Australia, with an average annual incidence of just five cases per 100,000 people. The bacterial infection is fully preventable and curable with timely medical intervention, but poses a severe mortality risk to patients who do not receive prompt treatment.

    Following public health guidance, the centre has launched precautionary measures to contain any potential spread. Close contacts of the infected child, including both enrolled children and centre staff, have been prioritized for free testing arranged jointly by Public Health Tasmania and the Launceston General Hospital. The facility has remained open throughout the process, maintaining its usual rigorous hygiene and cleaning protocols to protect visitors and staff.

    In a statement, the Goodstart Early Learning spokesperson confirmed that the centre has followed both public health directives and its own internal infectious disease policies since receiving notification of the case. Centre leadership began reaching out to all parents this week to share full information from health authorities, noting that the overall risk of transmission to most families and educators remains low.

    Parents with any concerns about potential exposure have been urged to reach out to their local general practitioner or call the Tasmanian public health hotline at 180 671 738 for guidance and more information.

  • In Benin, malnutrition and misinformed views contribute to widespread stunting in children

    In Benin, malnutrition and misinformed views contribute to widespread stunting in children

    In the rural commune of N’dali in northern Benin, smallholder farmer Sabi Bera Zakari holds a common but dangerous misperception about childhood malnutrition. While he occasionally worries that his children do not gain enough weight, he does not see stunted growth — impaired height development from chronic poor nutrition — as a problem to address. His view is not an anomaly in this dry, drought-prone region, where decades of efforts to curb stunting have failed to reverse one of the highest prevalence rates on the African continent.

    Development sociologist Boris Gloni, a former representative for The Hunger Project who has worked on anti-hunger initiatives across Benin for years, quickly identified that two of Zakari’s young daughters show clear signs of stunting. For years, Gloni has worked to shift harmful cultural and knowledge gaps around the condition, which the Global Alliance for Improved Nutrition (GAIN) reports affects more than 30% of all children under age 5 in Benin — a startling statistic for a nation rich in natural resources with a widespread tradition of small-scale subsistence farming.

    Stunting, defined as height below the average for a child’s age caused by chronic malnutrition, often hides in plain sight: children who experience it may appear outwardly healthy to untrained parents. But public health experts warn that stunting that occurs during a child’s first 1,000 days — from conception to age two — is almost always irreversible, causing permanent damage to cognitive development and long-term physical health that limits opportunities throughout a person’s life.

    Deep-rooted misinformation and cultural norms are major barriers to progress. Gloni notes that many community members incorrectly believe feeding children protein-rich foods like milk and eggs regularly will make them permanently greedy, pushing them to steal to satisfy their cravings. Most households raise goats and chickens not for family consumption, but as a living emergency fund — animals are sold for cash only when a crisis hits, and even eggs are often sold rather than fed to growing children. “Our perception is wrong,” Gloni said. “People don’t have knowledge.”

    Dietary habits worsen the problem, compounded by worsening climate volatility. Most rural families in northern Benin rely heavily on starchy staples such as yams, cassava and maize, with almost no variation to add protein, vitamins or micronutrients. Many women work long hours in their garden plots from dawn to late afternoon, leaving young children without consistent access to food throughout the day, which further erodes nutrition.

    Northern Benin, a region of dry savannah, faces repeated, sporadic drought that disrupts crop and livestock production. In the most severe dry seasons, entire families survive on foraged wild vegetable soup, with almost no nutrient intake. Benin’s government has set a target to reduce national stunting prevalence to below 30% by 2030, but progress so far has been discouraging.

    Community volunteers like Douro Wonkourou Idrissou, a nutrition support worker in N’dali, travel door-to-door to screen children for malnutrition using color-coded measuring tapes that assess wasting by measuring upper arm circumference. While he cannot conduct formal height screenings for stunting, Idrissou says he feels deep sadness when he sees children falling far short of healthy growth markers. He says parents bear some responsibility for poor nutrition outcomes, but also lack the support and knowledge to make changes.

    Rolland Essou, who coordinates The Hunger Project’s work in northern Benin, says that despite years of intervention, stunting rates in the region have stagnated — and some data even shows national rates rising, not falling. This includes after the launch of the World Bank-funded “1,000 Days” program, a pilot initiative run by Benin’s National Agency for Food and Nutrition that began in 2024. The program provides micronutrient supplements for pregnant people and infants, and has established school canteens serving daily hot meals, but these efforts have not yet moved the needle on overall prevalence.

    Essou explains that systemic barriers will keep stunting a major challenge for years to come. Households most affected by childhood malnutrition tend to be led by young, illiterate parents with multiple children to feed, stretching limited resources even thinner. Zakari, for example, could not immediately name the ages of his children, and had to check his national ID to confirm his own age.

    Zakari’s neighbor Fati Aboubacar, a mother of five, says economic constraints make proper nutrition impossible for many families. Her household can only afford to serve eggs once a week. Even families that own livestock often cannot justify using them for food, Aboudou Salamatou, Zakari’s wife, explained: “When a chicken pecked at the dirt near her feet, she said the bird was one of many kept as money ‘in the bank,’ not for eating. Even the eggs the chickens lay may be sold for cash. “We would like to vary our food, but we don’t have the means,” she said. “When we have a little money, we invest it in the field, in health and in other problems.”

    NGO workers say intervention needs to begin even before birth to be effective. Razak Kotchoni, project manager for CASCADE Benin in Borgou, says the same harmful cultural norms that bar children from regular protein consumption also apply to pregnant people. Pregnant women are often discouraged from eating nutrient-dense cornmeal porridge because of the myth that it will cause excessive, uncontrollable hunger. “These standards are contributing factors to malnutrition,” Kotchoni said.

    His organization deploys community facilitators to lead reflective dialogues with elders, parents and other community members to challenge harmful traditional practices. One successful strategy has been training “model mothers” who demonstrate healthy nutrition practices to spread awareness through peer outreach. While some parents now reach out to volunteers like Idrissou when they notice their children are not growing properly, many others remain indifferent to the risk, he says.

    As Benin works toward its 2030 target, public health workers and community volunteers say closing knowledge gaps and addressing deep systemic poverty will be critical to turning the tide on a preventable public health crisis that robs generations of children of healthy development.

  • Congo to receive 70,000 doses of Ervebo Ebola vaccine which has been effective in past outbreaks

    Congo to receive 70,000 doses of Ervebo Ebola vaccine which has been effective in past outbreaks

    BUNIA, Democratic Republic of Congo – The World Health Organization, alongside global health partners, announced Thursday that the Democratic Republic of Congo (DRC) will soon receive 70,000 doses of the Ervebo vaccine, a move widely regarded as a critical reinforcement for local efforts to curb what health officials have called the fastest-moving Ebola outbreak on record.

    Ervebo, a vaccine that has proven effective at stopping Ebola outbreaks in previous public health emergencies, is formally approved to provide protection against the Zaire ebolavirus – one of the viral species that causes Ebola disease. It has not been authorized for use against the Bundibugyo virus, the specific pathogen driving the current outbreak in eastern DRC.

    In an official statement, WHO noted that while the full extent of Ervebo’s ability to protect against Bundibugyo remains unconfirmed, early findings from laboratory and animal studies indicate the vaccine could offer at least partial immunity against this strain. Of the 70,000 doses being allocated to Congo, 20,000 will be deployed for a Phase 3 clinical trial designed to formally measure how effective Ervebo is against the Bundibugyo virus. The remaining 50,000 doses will be prioritized for frontline medical workers and response teams, under guidance from WHO technical experts.

    As of the latest update, the ongoing outbreak in eastern Congo has recorded 5,208 confirmed cases, with 2,476 recorded deaths. The outbreak is spreading at an unprecedented pace: it has infected and killed more people more rapidly than any previous Ebola outbreak in history, moving roughly three times faster than the 2014-2016 West African Ebola epidemic, which remains the deadliest on record with more than 11,000 fatalities across the region.

    Responders have faced major structural challenges since the outbreak began. No vaccines or therapeutic treatments have ever been formally approved for the rare Bundibugyo virus, leaving response teams with few evidence-based tools to slow transmission. Further complicating containment efforts, the majority of new confirmed cases are being detected in communities that were not under active public health surveillance, a sign that the virus has spread widely and left contact tracing teams scrambling to contain undetected chains of transmission.

  • Vaccine breakthrough stops cancer returning in trial

    Vaccine breakthrough stops cancer returning in trial

    A groundbreaking clinical trial has delivered encouraging early results for a novel personalized cancer vaccine, marking what experts describe as a potential turning point in the global fight against skin cancer. Developed in a collaborative partnership between pharmaceutical giants Merck & Co. (known as MSD outside the United States) and biotechnology leader Moderna, the experimental treatment combines the newly developed vaccine, branded Intismeran, with Keytruda – a widely used existing immunotherapy drug for cancer care.

    The phase three clinical trial enrolled over 1,000 patients diagnosed with high-risk melanoma, the most aggressive form of skin cancer. All participants underwent surgical removal of their tumors before receiving either the combined vaccine-drug treatment or Keytruda as a standalone therapy. Early data released by the two companies shows that the combination therapy significantly extended cancer-free survival periods for patients and cut the risk of melanoma spreading to distant organs compared to single-drug treatment.

    Unlike traditional cancer treatments, this new therapy leverages the same mRNA technology that powered many widely used COVID-19 vaccines to create a one-of-a-kind treatment tailored to each patient. To develop the personalized jab, scientists first sequence the DNA of a small sample taken from the patient’s tumor during surgery. This genetic data allows them to design a vaccine that targets unique mutations present in the patient’s cancer cells, training the immune system to specifically identify and attack any remaining cancer cells that may cause recurrence.

    Clinical and public health leaders have welcomed the early findings, while urging caution as the full trial data has not yet been published or subjected to independent peer review. Professor Peter Johnson, National Clinical Director for Cancer at NHS England, called the development an exciting advance in immuno-oncology. “Most existing cancer immunotherapies work by broadly freeing up the immune system to target cancer, but this new approach directly directs the immune system to the patient’s unique tumor,” Johnson explained in an interview with the BBC’s Today Programme. He added that the NHS is already making preparations to roll out this new class of treatment to patients once it receives regulatory approval.

    Dr. Lennard Lee, a consultant medical oncologist and associate professor at the University of Oxford, noted that the results carry implications far beyond melanoma treatment. “This trial provides the first large-scale proof of principle that personalized cancer vaccines actually work,” Lee said. Cancer Research UK’s head of prevention and early detection, Dr. Talisia Quallo, echoed the cautious optimism, stating that “this research shows real promise, but the interim data must undergo full independent review before we can draw definitive conclusions. Continued investment in this line of research is critical to expanding access to personalized treatment that helps more cancer patients live longer, higher-quality lives.”

    Moderna CEO Stephane Bancel described the trial outcome as a “pivotal moment” for cancer research worldwide. Beyond melanoma, the two companies are already running clinical trials for similar personalized mRNA vaccines targeting three other common cancer types: lung, bladder, and kidney cancer. Following the announcement of the early results, share prices for both Moderna and Merck rose sharply in global markets.

    Even if the trial’s positive results hold up through full review, the treatment still faces multiple regulatory and access hurdles. It must first receive formal approval from global medical regulators, followed by a separate approval process before it can be made routinely available to patients through the UK’s National Health Service. Full detailed results from the phase three trial are scheduled to be presented at an international medical conference in October this year.