A groundbreaking study conducted by Chinese researchers has successfully established comprehensive normative references for brain structure across the entire lifespan of the Chinese population, marking a significant advancement in neurological diagnostics. The research, led by Professor Liu Ya’ou from the Department of Radiology at Beijing Tiantan Hospital, addresses critical gaps in neurological healthcare specific to Chinese patients.
The research initiative emerged from two fundamental challenges in China’s neurological diagnostics landscape. First, existing brain normative standards predominantly derive from Western populations, creating potential inaccuracies when applied to Chinese patients due to distinct genetic backgrounds and environmental factors. Second, the medical community lacked sufficient data to differentiate between normal aging processes and pathological neurological changes, often resulting in delayed diagnoses and missed intervention opportunities.
To overcome these limitations, the collaborative team from Beijing Tiantan Hospital and Beijing Normal University analyzed an extensive dataset comprising magnetic resonance imaging scans from 24,061 healthy Chinese individuals and 3,932 patients with neurological disorders. Their comprehensive analysis established standardized reference ranges for 228 critical structural indicators specifically tailored to the Chinese population.
Published in the prestigious international journal Nature Neuroscience, the findings demonstrate how individual brain deviation scores calculated from these normative references can rapidly quantify structural abnormalities and facilitate precise disease identification. The research reveals distinct neurological patterns: Alzheimer’s disease manifests through widespread deviations across multiple brain structures, Parkinson’s disease primarily affects deep gray matter, while multiple sclerosis predominantly involves white matter and thalamus volume alterations.
This innovative framework, currently undergoing clinical pilot testing at Beijing Tiantan Hospital, enables earlier screening and diagnosis of neurological disorders while supporting more targeted treatment strategies. The research team is expanding collaborations with medical imaging corporations to integrate multi-modal imaging, blood biomarkers, and genetic testing data, further advancing precision medicine approaches for brain health and major neurological conditions.









