A catastrophic cargo plane crash at Louisville International Airport on Tuesday evening has resulted in at least seven fatalities, with fears that the death toll may rise. The UPS-operated flight 2976, an MD-11F aircraft, veered off the runway during takeoff at approximately 17:15 local time, igniting a massive fire that engulfed nearby buildings. The incident has triggered a large-scale emergency response to contain the blaze and mitigate further risks. Kentucky Governor Andy Beshear confirmed that two businesses, Kentucky Petroleum Recycling and Grade A Auto Parts, were directly impacted by the crash. Unverified footage shows the plane already ablaze as it skidded off the runway. The fire spread rapidly, prompting authorities to issue shelter-in-place orders for residents within a one-mile radius due to concerns over air pollution and potential explosions. All airport operations have been suspended indefinitely. Officials have reported eleven injuries so far, with the number expected to increase. The cause of the crash remains under investigation, though the substantial fuel load on the aircraft, which was en route to Hawaii, likely exacerbated the fire. Louisville Fire Department Chief Brian O’Neal described the scene as “very dangerous” due to the spilled fuel. Searches are ongoing to locate two missing workers from the auto parts business, and it remains unclear how many customers were present at the time of the crash. The MD-11F, a triple-engine cargo plane, has been in service for 34 years. Authorities have assured the public that the aircraft was not carrying hazardous materials.