Nigeria has embarked on an unprecedented nationwide vaccination campaign, one of the largest in its history, aiming to safeguard approximately 106 million children against measles, rubella, and poliomyelitis. This integrated initiative combines multiple vaccines and essential child health services into a unified effort, ensuring efficient and comprehensive protection across the country. Children aged 14 and below will receive measles and rubella vaccines, while those under five will be immunized against polio. The campaign is being rolled out in two phases: the first, launched on October 7, 2025, targets 20 high-risk northern states and Oyo state in the southwest, while the second phase, scheduled for January 2026, will cover the remaining southern states. Gavi, a global health organization, is supporting the campaign with a $103 million investment, collaborating with federal and state governments to strengthen health systems, share expertise, and ensure long-term sustainability. The initiative leverages years of investment in Nigeria’s health infrastructure, including cold chain systems, workforce capacity, and digital tools, while also utilizing data and technology to enhance decision-making, track progress, and boost public engagement.