The upcoming G20 Summit in Johannesburg, South Africa, is poised to catalyze a profound reassessment among Global South nations regarding their historical ties with the Global North. James Shikwati, director of the Nairobi-based Inter Region Economic Network, highlights that this summit could accelerate the Global South’s pivot toward emerging alliances like BRICS, as they seek to capitalize on new opportunities. This shift underscores a growing desire for greater autonomy and strategic diversification in international relations. The summit’s location in Africa further amplifies its symbolic importance, offering a platform for developing nations to assert their voices on the global stage. As the Global South increasingly explores alternative partnerships, the traditional North-South paradigm faces unprecedented challenges, potentially reshaping the geopolitical landscape.