The global fight against malaria has hit a critical roadblock after two decades of significant progress, with climate change and population growth emerging as major threats to the eradication of this deadly disease. Campaigners have raised alarms over insufficient funding for increasingly expensive prevention programs, which could result in hundreds of thousands of lives lost and billions of dollars in economic damage. The African Leaders Malaria Alliance (ALMA) and Malaria No More UK highlighted these concerns in a recent report, emphasizing that Africa, which accounts for 95% of global malaria cases, would bear the brunt of this resurgence. In 2023, malaria claimed 590,000 lives worldwide, with 263 million cases reported—an increase of 11 million from the previous year. Climate change has exacerbated the issue, with rising temperatures and heavy rainfall creating more mosquito breeding sites, even at higher altitudes in regions like Rwanda. Additionally, the spread of the Anopheles stephensi mosquito from Asia into Africa and increasing insecticide resistance have further complicated efforts. While new-generation prevention methods, such as dual-insecticide mosquito nets and drone-dispersed larvicides, have shown promise, their high costs and the need to cover a rapidly growing population pose significant challenges. Malaria remains a leading cause of worker and student absenteeism, cognitive disruption in children, and household poverty. Campaigners stress that eliminating malaria would yield substantial economic benefits, including increased productivity and tourism. However, without adequate funding and global cooperation, the situation could worsen dramatically. Funding models predict that halting all prevention efforts could cost Africa $83 billion in lost GDP by 2030, alongside 525 million additional cases and 990,000 more deaths. The report was released ahead of a crucial meeting in South Africa to secure contributions to the Global Fund to Fight AIDS, TB, and Malaria, which currently covers 59% of malaria spending.