Arsenal’s Premier League title aspirations face a significant challenge as key defender Gabriel is likely to miss the highly anticipated clash against Tottenham Hotspur due to a thigh injury. The Brazilian centre-back, a linchpin in Mikel Arteta’s defensive setup, sustained the injury during Brazil’s friendly against Senegal, casting a shadow over Arsenal’s preparations for the North London derby. Gabriel’s absence could disrupt Arsenal’s defensive solidity, particularly in aerial duels, where he has been dominant this season. The Gunners, currently leading the league by four points over Manchester City, are already grappling with fitness concerns surrounding Martin Odegaard and Gabriel Martinelli. Former England striker Alan Shearer emphasized Gabriel’s irreplaceability, stating, ‘Arsenal are losing probably the best centre-half in the Premier League.’ Potential replacements include Piero Hincapie, Cristhian Mosquera, or a positional switch for Riccardo Calafiori. Meanwhile, Tottenham, under new manager Thomas Frank, boast the league’s best away record and have shown resilience despite injuries to key attackers like James Maddison and Dejan Kulusevski. A victory for Spurs could reignite the title race and intensify the battle for Champions League qualification. Elsewhere, Manchester City, led by the prolific Erling Haaland, aim to maintain their momentum against Newcastle United, while Liverpool seek to recover from a dismal run against Nottingham Forest. Manchester United, riding a five-game unbeaten streak, will look to continue their resurgence against Everton.