Iranian President Masoud Pezeshkian has issued a grave warning that any military strike targeting Supreme Leader Ayatollah Ali Khamenei would be interpreted as a declaration of comprehensive warfare against the Iranian nation. This stern pronouncement emerged amidst escalating diplomatic hostilities between Tehran and Washington.
The presidential statement, disseminated via social media platform X on Sunday, constitutes a direct response to provocative remarks from US President Donald Trump. In an interview with Politico published Saturday, Trump explicitly called for regime change in Iran, asserting that ‘the time has arrived to seek new leadership in Iran.’
President Pezeshkian’s communiqué further attributed Iran’s economic challenges to what he characterized as ‘persistent antagonism’ and ‘cruel sanctions’ enforced by the United States and allied nations. He maintained these measures have principally instigated the hardships confronting ordinary Iranian citizens.
The diplomatic confrontation intensified earlier when Supreme Leader Khamenei personally denounced Trump as a ‘criminal,’ alleging his responsibility for casualties and destruction during recent domestic turmoil in Iran. Bilateral relations have remained profoundly strained since Trump’s return to executive power, marked by the perpetuation of maximum pressure tactics and recurrent verbal clashes between the two administrations.
This exchange represents the most severe rhetorical escalation since the renewal of tensions, highlighting the fragile state of US-Iran relations and raising concerns about potential miscalculation that could precipitate open conflict.