A groundbreaking study published in the international journal *Nature Cardiovascular Research* highlights that women may experience significantly greater cardiovascular benefits from exercise compared to men. Conducted by a collaborative team led by Professor Wang Yan and Associate Researcher Chen Jiajin from Xiamen Cardiovascular Hospital Xiamen University and Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, the research analyzed wearable device data from 85,000 participants. The findings reveal that women need only 250 minutes of weekly exercise to reduce their risk of coronary heart disease by 30%, whereas men require 530 minutes to achieve the same level of protection. For individuals already diagnosed with coronary heart disease, women exercising 51 minutes weekly can lower their mortality risk by 30%, while men need 85 minutes for similar results. Coronary heart disease remains a leading cause of death globally, with organizations like the World Health Organization recommending at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity weekly activity for adults. The study challenges the ‘one-size-fits-all’ approach to exercise guidelines, advocating for gender-specific recommendations to optimize heart disease prevention and treatment.