Millions of diabetes patients worldwide may soon bid farewell to the discomfort of daily insulin injections, thanks to a groundbreaking discovery by Chinese researchers. A team led by scholars from Zhejiang University has achieved the world’s first non-invasive delivery of insulin through the skin, offering a pain-free alternative with efficacy comparable to traditional injections. The findings, published in the prestigious journal Nature, mark a significant leap in diabetes treatment. The innovative approach utilizes a polymer called OP, which exhibits exceptional permeability in skin tissues, enabling the delivery of insulin without disrupting the skin barrier. This breakthrough not only addresses the physical and psychological challenges associated with injections but also opens doors for the transdermal delivery of other biological macromolecules, such as therapeutic proteins and monoclonal antibodies. The technology, already transferred to enterprises for clinical translation, holds immense potential to revolutionize treatment for chronic diseases requiring long-term injections.