The 2025 World University Presidents Forum, held in Hangzhou, Zhejiang province, brought together over 170 leaders from academia, government, and industry across 40 countries to explore the transformative role of artificial intelligence (AI) in higher education. Co-hosted by the China Association of Higher Education and Zhejiang University (ZJU), the forum emphasized the need for innovation, ethical considerations, and global collaboration in integrating AI into teaching, learning, and university governance. Vice-Minister of Education Ren Youqun highlighted the importance of risk prevention, expanded data access, and ethical rationality as AI continues to evolve. A key outcome of the forum was the launch of the Global University Collaborative Mechanism for Innovation in AI Education and Teaching, which includes 78 founding member universities from China and abroad. This initiative will publish a white paper on AI literacy, develop global open courses, and introduce ‘AI+X’ micro-programs under the STEP (Start, Train, Explore, Progress) framework. ZJU President Ma Yanming shared insights into the university’s AI STEP Initiative, which aims to foster AI-empowered education and cultivate students as innovators. Concurrently, the 2025 International Forum on Higher Education released the Hangzhou Initiative, advocating for human–machine collaboration in talent cultivation, intelligent research paradigms, AI-enhanced governance, and global innovation in education. Ren Shaobo, Chairman of the ZJU Council, reiterated the university’s commitment to nurturing innovative talent and exploring AI-driven governance models. UNESCO’s Shahbaz Khan underscored the broader societal impact of AI, emphasizing its potential to support equity, sustainability, and peace. The forum marked a significant step toward reshaping global higher education in the AI era.