In a landmark development at the 20th Annual Meeting of the International Conference on Genomics (ICG-20) in Hangzhou, BGI-Research and Zhejiang Lab unveiled Genos, an open-source Human-Centric genomic foundation model. This cutting-edge innovation, designed to operate at single-nucleotide precision across ultra-long DNA sequences, leverages high-quality human genomes from diverse global ancestries. Genos promises transformative applications across multiple domains, including public health, developmental biology, and scientific research. In public health, it enhances disease monitoring and informs targeted preventive measures. In developmental biology, it sheds light on gene regulation in tissue and organ formation. For scientific research, it predicts RNA expression from DNA sequences in seconds, a process that previously took weeks or months. Integrated into BGI’s DCS Cloud and the CNGB database, Genos empowers researchers to forecast cell expression levels, identify key candidate genes, and accelerate discoveries. Clinically, it collaborates with BGI’s GeneT deep reasoning model to diagnose genetic diseases, while in personal health, it generates personalized genomic reports via BGI’s BGE platform. The development of Genos was spearheaded by a cross-disciplinary team from the Foundation Model Training Program, a joint initiative by BGI-Research and Zhejiang Lab. This program united bioinformatics experts and computing specialists, fostering interdisciplinary collaboration that is driving life science research from data mining toward emergent intelligence.