In a significant step toward global agricultural sustainability, the BRI International Alliance of Science and Technology Innovation in Plant Protection was officially launched during the 2nd International Symposium on Plant Biosafety in Guangzhou, Guangdong province. The event, held from November 2 to 6, brought together over 250 experts and scholars from 18 countries and more than 40 domestic institutions. The alliance, a collaborative effort between the Chinese Academy of Agricultural Sciences’ Institute of Plant Protection and the Center for Agriculture and Bioscience International (CABI), aims to strengthen international cooperation in plant health and food security. Sun Tan, vice-president of the academy, emphasized the critical role of plant biosafety in addressing global food security and sustainable agricultural development. He highlighted that plant pests and diseases cause annual yield losses of 20 to 40 percent, resulting in over $220 billion in economic damage worldwide. The academy pledged to enhance international collaboration in biosafety research, improve cooperation mechanisms, and promote joint innovation platforms. Daniel Elger, CEO of CABI, underscored the fruitful partnership between China and CABI over the past three decades, expressing commitment to deepening collaboration for the global sharing and application of plant biosafety management technologies. The symposium also facilitated discussions on pest and disease outbreak patterns, integrated pest management, and innovative biosafety governance approaches.